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Query: DHX8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DHX8 1 5.609 -3.130 5.770 0.635 -0.697 -0.009

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DHX8 Phosphorylation S460 -0.090 _QSMDMS(ph)PIK_

Background Information for DHX8:


Pubmed-DHX8 »
Uniprot-DHX8 »
Biogrid-DHX8 »
ProteomicsDB-DHX8 »

Tumorportal-DHX8 »
COSMIC-DHX8 »
GenomeRNAi-DHX8 »
Genecards-DHX8


Protein-protein Interactions for DHX8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCAS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC12 Cat. description Hein, Mann, Cell 2015
Category members IP bait CRNKL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ISY1;RAB43 Cat. description Hein, Mann, Cell 2015
Category members IP bait SNW1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHCHD10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H1T Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DHX8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members Rbsml_prot_S1_RNA-bd_dom IPR003029 0.15
Category members S1_dom IPR022967 0.15
Category members DUF1605 IPR011709 0.02
Category members T2SS_protein-E IPR001482 0
Category members Helicase-assoc_dom IPR007502 0


Protein complexes (CORUM database) featuring DHX8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1181 C complex spliceosome Database 2.39


Categories featuring DHX8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005681 spliceosomal complex Database 3.88
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members GO Category GO:0004004 ATP-dependent RNA helicase activity Database 1.43
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0006396 RNA processing Database 0.17
Category members GO Category GO:0006810 transport Database 0


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