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Query: DARS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DARS 0 0.822 1.570 -0.930 0.071 -0.451 -0.110 0.364 0.361

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DARS Ubiquitylation K26 -0.709 _EIMDAAEDYAK(gl)ER_
DARS Ubiquitylation K74 0.587 _GK(gl)QCFLVLR_
DARS Ubiquitylation K103 -0.104 _QMVK(gl)FAANINK_
DARS Ubiquitylation K330 -0.126 _FQTEIQTVNK(gl)QFPCEPFK_

Background Information for DARS:


Pubmed-DARS »
Uniprot-DARS »
Biogrid-DARS »
ProteomicsDB-DARS »

Tumorportal-DARS »
COSMIC-DARS »
GenomeRNAi-DARS »
Genecards-DARS


Protein-protein Interactions for DARS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AIMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COMTD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait QARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDCBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DARS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members Asp/Asn-tRNA-synth_IIb IPR002312 0.4
Category members NA-bd_OB_tRNA IPR004365 0.35
Category members aa-tRNA-synth_II IPR006195 0.24
Category members aa-tRNA-synt_II IPR004364 0.15


Protein complexes (CORUM database) featuring DARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3040 Multisynthetase complex Database 1.78


Categories featuring DARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_201 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 0 3.57
Category members Pathway Pathway_202 REACTOME_TRNA_AMINOACYLATION 0 1.34
Category members GO Category GO:0006418 tRNA aminoacylation for protein translation Database 0.91
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members Pathway Pathway_409 KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 0.82
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0004812 aminoacyl-tRNA ligase activity Database 0.41
Category members GO Category GO:0004046 aminoacylase activity Database 0
Category members GO Category GO:0004815 aspartate-tRNA ligase activity Database 0


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