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Query: CRTC3

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CRTC3 0 1.301 0.900 -0.240

PTM Sites:

Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CRTC3 Phosphorylation S329 -0.324 0.818 _S(ph)NPSIQATLNK_
CRTC3 Phosphorylation S370 0.483 0.312 _LFSLS(ph)NPSLSTTNLSGPSR_
CRTC3 Phosphorylation S62 -0.324 0.089 _LTQYHGGS(ph)LPNVSQLR_
CRTC3 Phosphorylation S368 0.281 _LFS(ph)LSNPSLSTTNLSGPSR_

Background Information for CRTC3:





Protein-protein Interactions for CRTC3

Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CENPJ;DKFZp667E025 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HCCS Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1430 Cat. description Hein, Mann, Cell 2015
Category members IP bait LRP8 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPK8 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCDHB15 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC24C Cat. description Hein, Mann, Cell 2015
Category members IP bait MAGEA10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CRTC3

Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring CRTC3

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CRTC3

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0051289 protein homotetramerization Database 0.44
Category members GO Category GO:0008140 cAMP response element binding protein binding Database 0.3
Category members GO Category GO:0032793 positive regulation of CREB transcription factor activity Database 0


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