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Query: CIC

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CIC 0 2.301 0.680 -0.440 0.375

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CIC Phosphorylation S555 1.259 _EGS(ph)TEFDWGDETSR_
CIC Phosphorylation S1405 0.667 0.686 _KVFS(ph)PVIR_
CIC Phosphorylation T1080 0.592 _RT(ph)QSLSALPK_
CIC Phosphorylation S1082 0.326 0.465 _TQS(ph)LSALPK_
CIC Phosphorylation S1210 0.400 _SM(ox)S(ph)ETGTAAAPGVSSELLSVAAQTLLSSDTK_
CIC Phosphorylation S2288 -1.272 0.282 _FAELPEFRPEEVLPSPTLQSLATS(ph)PR_
CIC Phosphorylation S1340 0.249 _AAS(ph)EDMTSDEER_
CIC Phosphorylation S780 -1.409 -0.251 _SRQPS(ph)PLLLLPPPAGLTSDPGPSVR_
CIC Phosphorylation T2287 -1.204 -0.271 _FAELPEFRPEEVLPSPTLQSLAT(ph)SPR_
CIC Phosphorylation T472 0.464 -0.312 _ART(ph)PLTAAQQK_
CIC Phosphorylation S768 -0.020 -0.690 _AVS(ph)PAVPFSR_
CIC Phosphorylation S1811 -0.759 -0.785 _AQS(ph)VSPVQAPPPGGSAQLLPGK_
CIC Phosphorylation S2303 -0.918 _NS(ph)TDLDSAPEDPTS(ph)PK_
CIC Phosphorylation S2201 -0.888 -0.964 _GEPPTPPS(ph)PAPAPAVAPGGSSESSSGR_
CIC Phosphorylation S1813 -0.974 -0.965 _AQSVS(ph)PVQAPPPGGSAQLLPGK_
CIC Phosphorylation S2315 -2.460 -1.015 _NSTDLDSAPEDPTS(ph)PK_
CIC Phosphorylation S1014 -1.485 _EPAESAAVAHERPPGGTGSADPERPPGATCPES(ph)PGPGPPHPLGVVESGK_
CIC Phosphorylation S2279 -0.828 -1.622 _FAELPEFRPEEVLPS(ph)PTLQSLATS(ph)PR_
CIC Phosphorylation T2281 -1.811 _FAELPEFRPEEVLPSPT(ph)LQSLATS(ph)PR_
CIC Phosphorylation S776 -0.580 _S(ph)RQPSPLLLLPPPAGLTSDPGPSVR_
CIC Phosphorylation S2152 -1.459 _S(ph)SPPLPPPAEER_
CIC Phosphorylation S2153 -1.459 _S(ph)SPPLPPPAEER_

Background Information for CIC:


Pubmed-CIC »
Uniprot-CIC »
Biogrid-CIC »
ProteomicsDB-CIC »

Tumorportal-CIC »
COSMIC-CIC »
GenomeRNAi-CIC »
Genecards-CIC


Protein-protein Interactions for CIC
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CEP78 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CA Cat. description Hein, Mann, Cell 2015
Category members IP bait ATXN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF238 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CIC
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HMG_box_dom IPR009071 0.31


Protein complexes (CORUM database) featuring CIC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CIC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0


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