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Query: BCKDHA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BCKDHA 0 2.205 0.540 -0.360 0.748 -0.936

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BCKDHA Phosphorylation T372 0.965 _IGHHST(ph)SDDSSAYR_
BCKDHA Phosphorylation S371 1.428 0.919 _IGHHS(ph)TSDDSSAYR_
BCKDHA Phosphorylation S381 0.585 0.523 _S(ph)VDEVNYWDKQDHPISR_

Background Information for BCKDHA:


Pubmed-BCKDHA »
Uniprot-BCKDHA »
Biogrid-BCKDHA »
ProteomicsDB-BCKDHA »

Tumorportal-BCKDHA »
COSMIC-BCKDHA »
GenomeRNAi-BCKDHA »
Genecards-BCKDHA


Protein-protein Interactions for BCKDHA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HDAC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM5 Cat. description Hein, Mann, Cell 2015
Category members IP bait BCKDHB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPM1K Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BCKDHA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DH_E1 IPR001017 0.19
Category members THDP-binding IPR029061 0.04
Category members Transketolase_N IPR005474 0


Protein complexes (CORUM database) featuring BCKDHA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring BCKDHA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex Database 0.62
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Disease phenotype Classic_maple_syrup_urine_disease Classic maple syrup urine disease Database 0.32
Category members Disease phenotype Intermittent_maple_syrup_urine_disease Intermittent maple syrup urine disease Database 0.32
Category members Disease phenotype Maple_Syrup_Urine_Disease Maple Syrup Urine Disease Database 0.32
Category members Disease phenotype Thiamine-responsive_maple_syrup_urine_disease Thiamine-responsive maple syrup urine disease Database 0.32
Category members GO Category GO:0003826 alpha-ketoacid dehydrogenase activity Database 0.23
Category members GO Category GO:0003863 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity Database 0.23
Category members GO Category GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Database 0.19
Category members Disease phenotype Intermediate_maple_syrup_urine_disease Intermediate maple syrup urine disease Database 0.08
Category members Pathway Pathway_19 KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION 0 0.04
Category members GO Category GO:0034641 cellular nitrogen compound metabolic process Database 0.01
Category members Pathway Pathway_17 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 0 0
Category members Pathway Pathway_18 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM 0 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0009083 branched-chain amino acid catabolic process Database 0
Category members GO Category GO:0016831 carboxy-lyase activity Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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