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Query: AFF1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AFF1 0 -2.938 0.610 -0.490

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AFF1 Phosphorylation S213 -1.901 _ELSPLISLPS(ph)PVPPLSPIHS(ph)NQQTLPR_
AFF1 Phosphorylation S219 -2.354 _ELSPLISLPS(ph)PVPPLS(ph)PIHSNQQTLPR_
AFF1 Phosphorylation S223 -2.090 _ELSPLISLPS(ph)PVPPLSPIHS(ph)NQQTLPR_
AFF1 Ubiquitylation K335 -1.037 _TDLK(gl)VPAK_

Background Information for AFF1:


Pubmed-AFF1 »
Uniprot-AFF1 »
Biogrid-AFF1 »
ProteomicsDB-AFF1 »

Tumorportal-AFF1 »
COSMIC-AFF1 »
GenomeRNAi-AFF1 »
Genecards-AFF1


Protein-protein Interactions for AFF1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AFF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ELL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1BP Cat. description Hein, Mann, Cell 2015
Category members IP bait MLLT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH7 Cat. description Hein, Mann, Cell 2015
Category members IP bait RCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC16A6 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZNF526 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAMKV Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EAF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ELL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP4K2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AFF1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TF_AF4/FMR2 IPR007797 0


Protein complexes (CORUM database) featuring AFF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1457 AFF1-MLLT1-CBX8 complex Database 0.07


Categories featuring AFF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members Disease phenotype Precursor_B-cell_acute_lymphoblastic_leukemia Precursor B-cell acute lymphoblastic leukemia Database 0.25


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