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Query: ACTN3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ACTN3 2 4.815 1.770 -0.890 0.936 1.929 -1.407 0.572 0.293

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ACTN3 Ubiquitylation K125 1.906 _ALDFIASKGVK(gl)_
ACTN3 Ubiquitylation K760 0.273 1.507 _DAK(gl)GISQEQMQEFR_
ACTN3 Ubiquitylation K417 0.789 _LDHLAEK(gl)FR_
ACTN3 Ubiquitylation K592 -0.644 0.678 _EAILAIHK(gl)EAQR_
ACTN3 Ubiquitylation K350 0.585 _VQEK(gl)CQLEINFNTLQTK_

Background Information for ACTN3:


Pubmed-ACTN3 »
Uniprot-ACTN3 »
Biogrid-ACTN3 »
ProteomicsDB-ACTN3 »

Tumorportal-ACTN3 »
COSMIC-ACTN3 »
GenomeRNAi-ACTN3 »
Genecards-ACTN3


Protein-protein Interactions for ACTN3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AKAP17A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCHE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRCC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDLIM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ACTN3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Spectrin_repeat IPR002017 2.4
Category members Spectrin/alpha-actinin IPR018159 1.6
Category members CH-domain IPR001715 0.63
Category members CAMSAP_CH IPR022613 0.13
Category members EF_hand_dom IPR002048 0
Category members EF-hand_Ca_insen IPR014837 0


Protein complexes (CORUM database) featuring ACTN3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ACTN3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_1156 BIOCARTA_UCALPAIN_PATHWAY 0 1.12
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_889 KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 0 0.9
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_1178 BIOCARTA_CELL2CELL_PATHWAY 0 0.08
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03


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