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Query: ACIN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ACIN1 3 11.823 -1.320 2.580
ACIN1 3 11.823 -1.320 2.580 -0.089 -0.052
ACIN1 3 11.823 -1.320 2.580 0.965 0.602 0.873 0.087 0.204

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ACIN1 Phosphorylation S343 2.985 _FTRS(ph)QEEARK_
ACIN1 Phosphorylation S328 0.809 1.668 _S(ph)QEQEVLER_
ACIN1 Phosphorylation S125 0.905 1.500 _EAVVDLHADDS(ph)RISEDETER_
ACIN1 Phosphorylation S838 0.881 1.368 _GVPAGNS(ph)DTEGGQPGRK_
ACIN1 Phosphorylation S243 1.622 1.346 _LSEGS(ph)QPAEEEEDQETPSR_
ACIN1 Phosphorylation S710 2.140 1.025 _RLS(ph)QPESAEK_
ACIN1 Phosphorylation S365 0.699 0.841 _TTS(ph)PLEEEER_
ACIN1 Phosphorylation S128 0.843 0.751 _EAVVDLHADDSRIS(ph)EDETER_
ACIN1 Phosphorylation S240 0.857 0.730 _LS(ph)EGSQPAEEEEDQETPSR_
ACIN1 Phosphorylation S218 1.439 0.508 _KIS(ph)VVSTK_
ACIN1 Phosphorylation S657 0.357 0.450 _SLS(ph)PGVSR_
ACIN1 Phosphorylation S216 0.661 0.427 _SSSISEEKGDS(ph)DDEKPR_
ACIN1 Phosphorylation S825 1.333 0.415 _KIS(ph)VVSATK_
ACIN1 Phosphorylation S898 0.032 _SLIPDIKPLAGQEAVVDLHADDS(ph)RISEDETER_
ACIN1 Phosphorylation S729 0.345 0.031 _LQPERGS(ph)PKK_
ACIN1 Phosphorylation S987 0.625 -0.012 _S(ph)GVSITIDDPVR_
ACIN1 Phosphorylation S895 -0.112 -0.156 _SLIPDIKPLAGQEAVVDLHADDS(ph)RISEDETER_
ACIN1 Phosphorylation S1004 -0.186 -0.195 _TAQVPS(ph)PPR_
ACIN1 Phosphorylation S478 -0.138 -0.323 _ELLVSQHTVQLVGGLS(ph)PLSSPSDTK_
ACIN1 Phosphorylation S392 -0.275 -0.331 _AES(ph)PAEKVPEESVLPLVQK_
ACIN1 Phosphorylation S490 -0.275 -0.331 _AES(ph)PAEKVPEESVLPLVQK_
ACIN1 Phosphorylation S410 -0.677 -0.553 _ASLVALPEQTAS(ph)EEETPPPLLTK_
ACIN1 Phosphorylation S400 -0.080 -0.676 _KKAS(ph)LVALPEQTASEEETPPPLLTK_
ACIN1 Phosphorylation T414 -0.609 -0.833 _ASLVALPEQTASEEET(ph)PPPLLTK_
ACIN1 Phosphorylation T682 -0.729 -0.977 _DPSSGQEVAT(ph)PPVPQLQVCEPK_
ACIN1 Phosphorylation S326 -3.361 -1.435 _EAS(ph)SPPPHPQLHSEEEIEPMEGPAPPVLIQLS(ph)PPNTDADTR_
ACIN1 Phosphorylation S327 -1.435 _EAS(ph)SPPPHPQLHS(ph)EEEIEPMEGPAPPVLIQLS(ph)PPNTDADTR_
ACIN1 Phosphorylation T254 -1.213 -1.524 _LSEGSQPAEEEEDQET(ph)PSR_
ACIN1 Phosphorylation S336 -2.163 _EASSPPPHPQLHS(ph)EEEIEPMEGPAPPVLIQLS(ph)PPNTDADTR_
ACIN1 Phosphorylation S355 -3.237 -3.296 _EAS(ph)SPPPHPQLHSEEEIEPMEGPAPPVLIQLS(ph)PPNTDADTR_
ACIN1 Phosphorylation S377 3.085 _TTSPLEEEEREIKSS(ph)QGLK_
ACIN1 Phosphorylation S481 -0.454 _ELLVSQHTVQLVGGLS(ph)PLS(ph)SPSDTKAESPAEKVPEESVLPLVQK_
ACIN1 Ubiquitylation K548 0.442 _GITEECLK(gl)QPSLEQK_

Background Information for ACIN1:


Pubmed-ACIN1 »
Uniprot-ACIN1 »
Biogrid-ACIN1 »
ProteomicsDB-ACIN1 »

Tumorportal-ACIN1 »
COSMIC-ACIN1 »
GenomeRNAi-ACIN1 »
Genecards-ACIN1


Protein-protein Interactions for ACIN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC9 Cat. description Hein, Mann, Cell 2015
Category members IP bait ESRRB Cat. description Hein, Mann, Cell 2015
Category members IP bait LGALS3BP Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015
Category members IP bait SGTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ARRB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C11orf57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAMKV Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DENND2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ELAVL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPB41L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INSL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LUC7L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LUC7L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP4K2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRPF40A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SARNP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRPK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM184B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait U2AF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait U2AF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VTI1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WSB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ACIN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAP_dom IPR003034 1.96


Protein complexes (CORUM database) featuring ACIN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 760 Apoptosis- and splicing-associated protein complex (ASAP-L), SAP18-RNPS1-Acinus-L Database 0.57
Category members Corum 761 Apoptosis- and splicing-associated protein complex (ASAP-S), SAP18-RNPS1-Acinus-S Database 0.57


Categories featuring ACIN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members GO Category GO:0048025 negative regulation of mRNA splicing, via spliceosome Database 2.79
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0061574 ASAP complex Database 0.57
Category members GO Category GO:0035145 exon-exon junction complex Database 0.28
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0030218 erythrocyte differentiation Database 0.13
Category members GO Category GO:0045657 positive regulation of monocyte differentiation Database 0.05
Category members GO Category GO:0030263 apoptotic chromosome condensation Database 0.04


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