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Query: ABCA3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ABCA3 0 1.282 -0.670 0.640

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ABCA3 Ubiquitylation K1672 0.589 _VFGILEK(gl)AK_
ABCA3 Ubiquitylation K305 -0.010 _LTVTIK(gl)R_
ABCA3 Ubiquitylation K1674 0.053 -0.096 _VFGILEKAK(gl)_
ABCA3 Ubiquitylation K1092 -0.188 _SALQAAK(gl)DQFNEGR_
ABCA3 Ubiquitylation K81 -0.627 _NYTLQK(gl)R_
ABCA3 Ubiquitylation K507 -0.904 -0.640 _AVAGK(gl)EEEDSDPEK_

Background Information for ABCA3:


Pubmed-ABCA3 »
Uniprot-ABCA3 »
Biogrid-ABCA3 »
ProteomicsDB-ABCA3 »

Tumorportal-ABCA3 »
COSMIC-ABCA3 »
GenomeRNAi-ABCA3 »
Genecards-ABCA3


Protein-protein Interactions for ABCA3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACCN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD79B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHRND Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR114 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MANSC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCOLN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MPPE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHB16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PMEL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCTN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM9B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMPRSS12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UPK1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNRF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ABCA3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members AAA+_ATPase IPR003593 0.38
Category members ABC_transporter-like IPR003439 0.15


Protein complexes (CORUM database) featuring ABCA3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ABCA3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members Pathway Pathway_756 KEGG_ABC_TRANSPORTERS 0 0.13
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members GO Category GO:0042626 ATPase activity, coupled to transmembrane movement of substances Database 0.09
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members GO Category GO:0051384 response to glucocorticoid Database 0.04
Category members Pathway Pathway_757 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS 0 0
Category members Pathway Pathway_758 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT 0 0
Category members Disease phenotype Congenital_pulmonary_alveolar_proteinosis Congenital pulmonary alveolar proteinosis Database 0
Category members Disease phenotype Neonatal_acute_respiratory_distress_with_surfactant_metabolism_deficiency Neonatal acute respiratory distress with surfactant metabolism deficiency Database 0
Category members GO Category GO:0005215 transporter activity Database 0
Category members GO Category GO:0006810 transport Database 0


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