Results for the Category
Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma (Nikolaev Nat. Genet. 2011).
(pubmedid:22197931)
| RNAi screen result | RNAPII IP (MG132) | CSB IP | CSB IP (MG132) | Chrom. | Chrom. (MG132) | Ubi /Phospo | Ubi /Phospho (MG132) |
| W | |||||||
| Gene name | MGoogle Score | RNAi high | RNAi low | RNAPII-IP (MG132) | CSB-IP | CSB-IP (MG132) | Chrom. | Chrom. (MG132) |
|---|---|---|---|---|---|---|---|---|
| MAP2K1 | 1 | -1.590 | 2.780 | |||||
| MAP2K2 | 0 | -0.610 | 0.080 | |||||
| MAP2K2 | 0 | -0.610 | 0.080 |
| Gene name | PTM type | PTM site | UV | UV (MG132) | Sequence |
|---|---|---|---|---|---|
| MAP2K1 | Ubiquitylation | K192 | -0.205 | -0.241 | _DVK(gl)PSNILVNSR_ |
| MAP2K1 | Phosphorylation | S385 | 0.066 | _RSDAEEVDFAGWLCSTIGLNQPS(ph)TPTHAAGV_ | |
| MAP2K1 | Phosphorylation | T386 | 0.377 | _RSDAEEVDFAGWLCSTIGLNQPST(ph)PTHAAGV_ | |
| MAP2K2 | Phosphorylation | S23 | 0.873 | 0.258 | _RKPVLPALTINPTIAEGPS(ph)PTSEGASEANLVDLQK_ |
| MAP2K2 | Phosphorylation | T25 | 0.439 | _RKPVLPALTINPTIAEGPSPT(ph)SEGASEANLVDLQK_ | |
| MAP2K2 | Ubiquitylation | K192 | -0.205 | -0.241 | _DVK(gl)PSNILVNSR_ |
| MAP2K2 | Phosphorylation | S293 | -0.361 | _ELEAIFGRPVVDGEEGEPHS(ph)ISPR_ | |
| MAP2K2 | Phosphorylation | S295 | -0.234 | 0.026 | _ELEAIFGRPVVDGEEGEPHSIS(ph)PR_ |
| MAP2K2 | Phosphorylation | T394 | 0.570 | 0.158 | _LNQPGT(ph)PTR_ |
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